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Ultrastructural Changes of Thrombocytes During ADP-Stimulated Aggregation (in the Presence of Fibrinogen)

Belitser N. V., Anishchuk M. G., Pozdnyakova T. M., Gorkun O. V

 




The ultrastructure of resting and stimulated human blood platelets (P) was studied by the transmission electron microscopy. The cells were chemically fixed (using tannic acid and OsFeCN mixture) 1, 3, 5 and 15 min after the addition of ADP and fibrinogen (F). Early changes in P ultrastructure consist in drastic reduction of the electron-dense layer of glycocalyx and in an increase of the plasma membrane permeability. At the early stages of P aggregation the cells contact with each other due to rapidly arising pseudopodia. Later, the extracellular network containing an exogenous F participates in the aggregation process.

Tsitologiya i Genetika 1989, vol. 23, no. 3, pp. 3-7



Belitser N. V., Anishchuk M. G., Pozdnyakova T. M., Gorkun O. V Ultrastructural Changes of Thrombocytes During ADP-Stimulated Aggregation (in the Presence of Fibrinogen), Tsitol Genet., 1989, vol. 23, no. 3, pp. 3-7.




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