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Berezovskaya O.P., Sidorenko A.P., Mukha D.V.
Structural Characteristics of Osteopontin mRNA.
TSitologiia i genetika 2001, v 35, Issue 3, 35-42
Conservatism of primary and secondary structure of osteopontin mRNA in vertebrates of various taxes was studied using computer analysis and blot-hybridization procedure. Relatively high rate of evolution of a nucleotide sequence of osteopontin gene was revealed. Formation of hairpin-loop structures by adjacent sequences and a high content of AU-pairs indicate more flexible structure of the mammalian osteopontin mRNA as compared with the avian one. It has been detected some AU-enriched regions in 3´-terminal untranslated sequences, which presence is characteristic for short-lived mRNA. Evolutionary conserved subsequences in 3´- and 5´-terminal regions were suggested to be determinants of RNA-protein interaction in cytoplasm.
Berezovskaya O.P., Sidorenko A.P., Mukha D.V. Structural Characteristics of Osteopontin mRNA. // Tsitol Genet. – 2001. – 35(3). – P. 35-42.
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