Atramentova L. A., Ryzhko P. P., Fedota A. M.

Genetic Study of Psoriasis in Kharkov Population

Cytology and Genetics 2001, v 35, number 1, 74-78

400 pedigrees of men and women suffering from psoriasis were analyzed. The segregation frequencies in progeny of two healthy (SF_N×N = 0.083) and one affected parent (SF_N×A = 0.147) permitted to reject monogenic model of psoriasis inheritance. Near 100 % heritability of this disease in the polygenic model allowed to suggest existence of main susceptible gene and to estimate parameters of monogenic model with incomplete penetration (p = 0.044, P₁ = 6.1 %, P₂ = 82.2 %). According to this model 0.189 % of Kharkov population residents are homozygous and 8.32 % are heterozygous carriers of psoriatic gene, 0.155 % residents suffering from psoriasis are heterozygotes and 0.508 % are heterozygotes. 23 % of individuals suffering from psoriasis are homozygotes and 77 % heterozygotes.