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Chromatid Gaps as a Marker of the Mutagenic Effect of Environmental Pollution in Commensal and Wild Rodents of the Urals

Gileva E.A.

 




It was supposed earlier that achromatic gaps could be used as markers of the mutagenic effect of environmental pollution, especially under weaker clastogenic influences. The frequencies of true chromosome aberrations and those of achromatic gaps were estimated in house mice and common voles from 12–17 localities of the Urals with various mutagenic potential of environment. Gaps and breaks were distinguished according to the CBIS system. The increase in the frequency of cells with chromosome aberrations and gaps compared to background values was observed in the both species from several localities; only in the common vole, the P level for the gap increase was 0.056. The mean gap rate correlated significantly with that of chromosome aberrations not only with chromatid breaks, but also with the aberrations of other types. This parameter appears not to be a more sensitive indicator of environmental mutagens than true chromosome mutations, when mutagenic impact is not very powerful, as it was observed in the localities investigated. House mouse can be recommended as the effective test species for ecogenetic monitoring.

Tsitologiya i Genetika 2002, vol. 36, no. 4, pp. 17-22



Gileva E.A. Chromatid Gaps as a Marker of the Mutagenic Effect of Environmental Pollution in Commensal and Wild Rodents of the Urals, Tsitol Genet., 2002, vol. 36, no. 4, pp. 17-22.




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