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The number of aberrations on aberrant cell as a parameter of chromosome instability

Kutsokon N.K., Bezrukov V.F., Lazarenko L.M., Rashidov N.M., Grodzinsky D.M.

 


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Analysis of chromosome instability (CI) is of great importance in view of pollution of the environment by genotoxic factors. Frequency of aberrant cells, spectrum of chromosome aberrations, damages of aberrant cell and distribution of aberrations in the cells are the most conventional parameters of CI. We have carried out the comparative analysis of the frequency of aberrant cells and the dynamics of aberrant cell damages induced by different mutagenic factors (a-irradiation from 241Am, γ- irradiation from 60o and tioTEPA) in Allium-test. This comparative analysis denotes that the studied parameters have different dynamics characterizing different mechanism of CI in Allium cepaL.

Tsitologiya i Genetika 2003, vol. 37, no. 4, pp. 20-25



Kutsokon N.K., Bezrukov V.F., Lazarenko L.M., Rashidov N.M., Grodzinsky D.M. The number of aberrations on aberrant cell as a parameter of chromosome instability, Tsitol Genet., 2003, vol. 37, no. 4, pp. 20-25.




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