TSitologiya i Genetika 2004, vol. 38, no. 4, 49-54
Cytology and Genetics , vol. , no. , , doi: https://www.doi.org/

X chromosome inactivation patterns in elderly women aged over 70 years

Yurov I.Y., Villard L., Vorsanova S.G., Demidova I.A., Goyko E.A., Shal’nova S.A., Shkol’nikova M.A., Olferiev A.M., Yurov Y.B.

In the present study we have analyzed X chromosome inactivation patterns in 40 women aged from 74 to 85 years (mean age 78 years). The control group was 36 women (mean age 30 years). The most common AR-assay was used to determine X-inactivation patterns (the study of methylation patterns of HpaII site in human androgen receptor gene (HUMARA) by quantative PCR). The age dependence of X-inactivation was not observed. We have detected skewed X-inactivation in three women among 40 (7.5%) elderly women comparing to two women among 36 (5.5%) women from control group. The difference was not found to be statistically significant. We made a suggestion that higher incidence of skewed X-inactivation in elderly women revealed by previous studies could occur due to some experimental ambiguities as heterogeneity of the group studied; inclusion of women having relatives with genetic abnormalities associated with skewed X-inactivation patterns; the difference of X chromosome inactivation skewing determination. We conclude that present study does not show X chromosome inactivation to be age dependent.

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TSitologiya i Genetika
2004, vol. 38, no. 4, 49-54

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