Dosenko V.E., Mikhalchuk D., Zagoriy V.Yu., Parkhomenko A.N., Moibenko A.A.

The frequency of allelic polymorphism of genes encoding immunoproteasome catalytic subunits in acute coronary syndrome patients

Cytology and Genetics 2005, v 39, number 6, 50-54

Large multifunctional protease LMP2 (Arg₆₀®His) and LMP7 (Lys₁₄₅®Gln) gene allelic polymorphism in 200 patients with acute coronary syndrome and in 80 practically healthy people was determinated. It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphism is 52, 40.5 and 7.5 % correspondingly (in control group 53.8, 38.7, 7.5 %; Р > 0.05 by c²-test). Analysis of LMP7 gene polymorphism has shown that Lys/Lys – 89.5 %, Lys/Gln – 10.5 %, Gln/Gln – 0 % (in control group 93.8, 6.2, 0 % correspondingly; Р > 0.05). The data show that LMP2 and LMP7 gene polymorphism is not a risk factor of acute coronary syndrome in Ukrainian population.