Kaidashev I.P., Rasin M.S., Savchenko L.G., Shlykova O.A., Yakimishina L.I.

Polymorphism of the angiotensin II type 1 receptor in patients with essential hypertension in Ukrainian population

Cytology and Genetics 2005, v 39, number 5, 51-55

The distribution of polymorphism of the angiotensin II type 1 receptor in Ukrainian population was investigated. Healthy persons had genotypes AA (51 %), AC (34 %), CC (15 %) and alleles A (68 %), C (32 %). We suppose the prevalence of allele C and genotypes CC in health persons in Ukrainian population. The frequencies of genotypes and alleles in patients with essential hypertension were AA (22,85 %), AC (51,9 %), CC (25,3 %) and A (48,7 %), C (51,3 %). Thus the development of essential hypertension was associated with the presence of allele C and its homozygote variant. Moreover the severity and complications of hypertension depended on the presence of this allele and genotype. We concluded that Ukrainian population has specific distribution of polymorphism of the angiotensin II type 1 receptor with prevalence of allele C1166 and genotype CC. The presence of these genetic variants is a risk factor for essential hypertension.