Klimenko S.V., Misharina Zh.A., Abramenko I.V., Bilous N.I., Bebeshko V.G.

Determination of BCR/ABL translocation in radiation-associated acute myeloid leukemia patients by fluorescence in situ hybridization

Cytology and Genetics 2005, v 39, number 6, 55-59

We report the results of BCR/ABL translocation analysis on interphase leukemic cells of 33 acute myeloid leukemia (AML) patients by fluorescence in situ hybridization. Of these, there were 13 persons exposed to ionizing radiation due to the Chernobyl accident with radiation-associated AML and 20 patients with spontaneous disease. BCR/ABL translocation which was detected in 4 and 1 case respectively may play an important role in radiation-induced leukemigenesis.