Kovalenko O.О., Lukash L.L.

Induction of apoptosis in the populations of mammalian cells in vitro under the influence of lectins

Cytology and Genetics 2007, v 41, number 5, 48-53

The cytotoxiс action of lectins different in origin and carboxyl specificity has been studied. It has been shown that all types of lectins at high concentrations (20 µg/ml) were able to induce apoptosis in the in vitro populations of Chinese hamster cells two days after the treatment. In the case of Persa fluviatilis lectin this effect was detected immediately after the treatment and two days later as well. It was shown that Sambucus nigra lectin did not influence the frequency of apoptosis in the culture of human cells in contrast to the Lens culinaris and P. fluviatilis lectins. The tendency of stimulation of human cell proliferation under exposure to P. fluviatilis lectin at low concentration (0,2 µg/ml) has been registered.