Chakova N.N., Mikhalenko E.P., Polonetskaya S.N., Chebotareva N.V., Demidchik Yu.E., Zilko A.A., Kvitko O.V., Krupnova E.V.

GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients

TSitologiia i genetika 2009, v 43, Issue 1, 48-53

Carriers of GSTT1 gene deletion were found to be more subjected to a risk of emerging non-small-cell lung cancer (NSLC) than those of normal GSTT1(+) genotype. Study on the relation between GST gene polymorphism and cytogenetic indices in lung cancer patients has shown a significant excess of the group average level in cells with micronuclei in NSLC patients with GSTT1(–). The frequency of cells with micronuclei was higher in smoking patients with a mutant genotype than in smoking carriers of the GSTT1(+) genotype.

Chakova N.N., Mikhalenko E.P., Polonetskaya S.N., Chebotareva N.V., Demidchik Yu.E., Zilko A.A., Kvitko O.V., Krupnova E.V. GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients // Tsitol Genet. – 2009. – 43(1). – P. 48-53.