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Cytogenetic effects in peripheral blood lymphocytes in the offspring of Chernobyl nuclear power plant accident liquidators under the influence of mitomycin C in vitro and folic acid in vivo

Kovaleva V.I., Bagatskaya N.V.

 




SUMMARY. The data on cytogenetic examination concerning the offspring of the Chernobyl accident liquidators (cleanup personnel) have been obtained. It has been established that spontaneous chromosomal aberrations level before folic acid administration was 1,8 times higher than that value after its employment (4,45 to 2,42 %, p < 0,01). In lymphocyte cultures treated with mitomycin C accompanied by folic acid it was 4,5 times higher before their administration (23,95 to 5,36 %, p < 0,001). The data obtained confirm a possibility of stabilization of genetic apparatus in offspring of the Chernobyl disaster liquidators after folic acid administration.

Key words: the offspring of the Chernobyl accident liquidators, spontaneous and induced mutagenesis, folic acid, aberrations

Tsitologiya i Genetika 2013, vol. 47, no. 1, pp. 68-73

E-mail: iozdp ukrpost.ua

Kovaleva V.I., Bagatskaya N.V. Cytogenetic effects in peripheral blood lymphocytes in the offspring of Chernobyl nuclear power plant accident liquidators under the influence of mitomycin C in vitro and folic acid in vivo, Tsitol Genet., 2013, vol. 47, no. 1, pp. 68-73.

In "Cytology and Genetics":
V. I. Kovaleva, N. V. Bagatskaya Cytogenetic effects in peripheral blood lymphocytes in descendants of chernobyl disaster liquidators under the impact of mitomycin c in vitro and folic acid in vivo, Cytol Genet., 2013, vol. 47, no. 1, pp. 53-57
DOI: 10.3103/S0095452713010039


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