TSitologiya i Genetika 2013, vol. 47, no. 1, 68-73
Cytology and Genetics 2013, vol. 47, no. 1, 53-57, doi: https://www.doi.org/10.3103/S0095452713010039

Cytogenetic effects in peripheral blood lymphocytes in the offspring of Chernobyl nuclear power plant accident liquidators under the influence of mitomycin C in vitro and folic acid in vivo

Kovaleva V.I., Bagatskaya N.V.

SUMMARY. The data on cytogenetic examination concerning the offspring of the Chernobyl accident liquidators (cleanup personnel) have been obtained. It has been established that spontaneous chromosomal aberrations level before folic acid administration was 1,8 times higher than that value after its employment (4,45 to 2,42 %, p < 0,01). In lymphocyte cultures treated with mitomycin C accompanied by folic acid it was 4,5 times higher before their administration (23,95 to 5,36 %, p < 0,001). The data obtained confirm a possibility of stabilization of genetic apparatus in offspring of the Chernobyl disaster liquidators after folic acid administration.

Keywords: the offspring of the Chernobyl accident liquidators, spontaneous and induced mutagenesis, folic acid, aberrations

TSitologiya i Genetika
2013, vol. 47, no. 1, 68-73

Current Issue
Cytology and Genetics
2013, vol. 47, no. 1, 53-57,
doi: 10.3103/S0095452713010039

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