TSitologiya i Genetika 2016, vol. 50, no. 3, 46-56
Cytology and Genetics 2016, vol. 50, no. 3, 187–195, doi: https://www.doi.org/10.3103/S0095452716030099

Reduction of radiation­induced nitrative stress in leucocytes and kidney cells of rats upon administration of polyphenolic complex concentrates from red wine

Sabadashka M., Sybirna N.

Department of Biochemistry, Ivan Franko Lviv National University, Ukraine

The research has shown that exposure to ionizing radiation at the dose of 30 cGy leads to the activation of NO-synthase way of nitrogen oxide synthesis, as well as to the accumulation of its stable metabolites and 3-nitrotyrosine modified proteins in rat peripheral blood leucocytes and the renal cortical layer. NO-synthase activity was preserved at the control value through the consumption of red wine natural polyphenolic complex concentrates by the irradiated animals. The content of proteins modified by tyrosine nitration decreased in the early period of post-radiation exposure due to the influence of the investigated concentrate. Thus the ability of red wine natural polyphenolic complex concentrates to prevent adverse changes in L-arginine/NO system and, therefore, inhibit the development of nitrative stress induced by low doses of ionizing radiation has been proved experimentally.

Keywords: 3’-nitrotyrosine modified proteins, NO stable metabolites, NO-synthase, polyphenols, X-rays

TSitologiya i Genetika
2016, vol. 50, no. 3, 46-56

Current Issue
Cytology and Genetics
2016, vol. 50, no. 3, 187–195,
doi: 10.3103/S0095452716030099

Full text and supplemented materials

References