SUUMARY. The variations of certain biochemical blood parameters, cytokine and adypokine profiles, structural and functional parameters of the liver in nonalcoholic fatty liver disease patients with different genotypes by the polymorphic locus A313G of GSTP1 gene were investigated. G-allele of the GSTP1 gene (A313G) occured significantly more frequently in nonalcoholic fatty liver disease patients as compared to practically healthy individuals. Elevated alanineaminotransferase activity, higher leptin and lower adiponectin blood levels were observed in patients with G-allele in comparison with the corresponding figures in patients with AA-genotype. Nonalcoholic fatty liver disease patients G-allele homozygous carriers also experienced higher interleukin 10 blood level than patients with AA- and AG-genotypes. Larger right lobe of the liver was detected in patients with G-allele as compared to patients A-allele homozygous carriers.
Keywords: glutathione-S-transferase P1 gene, nonalcoholic fatty liver disease
