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Cyclooxigenase-1 gene polymorphism and aspirin resistance

Bondar T.N., Kravchenko N.A.


SUMMARY. The literature data concerning structure of cyclooxigenase-1 Ц the key enzyme in prostaglandin biosynthesis and the main target of anti-platelet therapy with the use of acetylsalicilic acid are presented in the review. The data on cyclooxigenase-1 gene polymorphism, distribution of the revealed variants in various populations and their possible correlation with biochemical and functional aspirin resistance are presented.

Key words: cyclooxigenase-1, thromboxane, polymorphism of cyclooxigenase-1 gene, platelets aggregation, aspirin, aspirin resistance

Tsitologiya i Genetika 2012, vol. 46, no. 4, pp. 66-72

E-mail: andbondar

Bondar T.N., Kravchenko N.A. Cyclooxigenase-1 gene polymorphism and aspirin resistance, Tsitol Genet., 2012, vol. 46, no. 4, pp. 66-72.

In "Cytology and Genetics":
T. N. BondarТ, N. A. Kravchenko Polymorphism of the cyclooxigenase-1 gene and aspirin resistance, Cytol Genet., 2012, vol. 46, no. 4, pp. 246-250
DOI: 10.3103/S0095452712040044

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