Cytology and Genetics 2012,
vol. 46,
no. 4, 246-250,
doi: https://www.doi.org/10.3103/S0095452712040044
SUMMARY. The literature data concerning structure of cyclooxigenase-1 – the key enzyme in prostaglandin biosynthesis and the main target of anti-platelet therapy with the use of acetylsalicilic acid are presented in the review. The data on cyclooxigenase-1 gene polymorphism, distribution of the revealed variants in various populations and their possible correlation with biochemical and functional aspirin resistance are presented.
Keywords: cyclooxigenase-1, thromboxane, polymorphism of cyclooxigenase-1 gene, platelets aggregation, aspirin, aspirin resistance