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Inhibiting effect of agmatine on genetically programmed death of leukocytes in experimental diabetes mellitus
Ferents I.V., Brodyak I.V., Lyuta M.Ya., Burda V.A., Sybirna N.O.
SUMMARY. This study is an attempt to elucidate of agmatine effects upon leukocyte apoptosis in experimental diabetes mellitus (EDM). We demonstrated the increase in numbers of the leukocytes with both early and late signs of apoptosis at diabetes. Further changes in the morphofunctional state of the leukocytes include the increased amount of fragmented DNA, elevated apoptotic index and violated ratio of p53 to Bcl-2 proteins. Agmatine has been shown to exert direct corrective effects on leukocyte apoptosis: the content of ð53 and Bcl-2 proteins was normalized, apoptotic index was decreased, the process of nuclear DNA degradation was ceased, while the amount of cells with early and late signs of apoptosis was diminished.
Key words: agmatine, leukocytes, apoptosis, experimental diabetes mellitus
Tsitologiya i Genetika 2016, vol. 50, no. 4, pp. 50-61
E-mail: sybirna_natalia  yahoo.com
Ferents I.V., Brodyak I.V., Lyuta M.Ya., Burda V.A., Sybirna N.O. Inhibiting effect of agmatine on genetically programmed death of leukocytes in experimental diabetes mellitus, Tsitol Genet., 2016, vol. 50, no. 4, pp. 50-61.
In "Cytology and Genetics":
I. V. Ferents, I. V. Brodyak, M. Ya. Lyuta, V. A. Burda, N. O. Sybirna Suppressive effect of agmatine on genetically programmed death of leukocytes in a diabetes model, Cytol Genet., 2016, vol. 50, no. 4, pp. 241–250
DOI: 10.3103/S0095452716040034
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