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The role of the genetic component in the pathogenesis of the osteopenic syndrome in children from ecologically unfavorable regions

Kech N.R., Hnatejko O.Z., Makukh H.V., Lukjanenko N.S., Lychkovska O.L.

SUMMARY. We studied the data of molecular-genetic and inst-rumental investigations for 125 children from ecologically unfavorable regions and 31 children of control group from an ecologically clear region. The investigation of polymorphous loci TaqI (rs731236) and АраI (rs739837) of vitamin D3 receptor was made by molecular-genetic method (polymerase chain reaction) among the children from ecologically unfavorable regions. Osteoporosis and osteopenia were diagnosed more frequently (1.5 times) in children from polluted environment. The main amount of bone mineral density (100 and 45 %) was in children with genotypes tt and Tt and children with genotypes AA and Aa (83 and 42 %), which is in good agreement with literature data. Comp-lex estimation of instrumental and clinical laboratory indicators was done in some allele variants of vitamin D3 receptor agents. Bone mineral density and bone system degree of changes were measured by ultrasound densitometry: bone mineral density < 67 % – osteoporosis, bone mineral density from 80 to 67 % – osteopenia, 100 +/– 20 % – normal bone mineral density, 120 %
and more – osteosclerosis. The investigation of poly-morphous loci TaqI and АраI of vitamin D3 receptor was made by molecular-genetic method (polymerase chain reaction) among the children with ecologically determined bone diseases.

Tsitologiya i Genetika 2018, vol. 52, no. 1, pp. 59-67

• Institute of Hereditary PathologyNational Academy of Medical Sciences of Ukraine, Lviv, Ukraine
• Danylo Halytsky Lviv National Medical University, Lviv, Ukraine

E-mail: NataliaKech ukr.net

Kech N.R., Hnatejko O.Z., Makukh H.V., Lukjanenko N.S., Lychkovska O.L. The role of the genetic component in the pathogenesis of the osteopenic syndrome in children from ecologically unfavorable regions, Tsitol Genet., 2018, vol. 52, no. 1, pp. 59-67.

In "Cytology and Genetics":
N. R. Kech, O. Z. Hnatejko, H. V. Makukh, N. S. Lukjanenko, O. L. Lychkovska Role of the genetic component in osteopenic syndrome pathogenesis in children from regions with a polluted environment, Cytol Genet., 2018, vol. 52, no. 1, pp. 46–53
DOI: 10.3103/S009545271801005X