SUMMARY. During the histological study, we had confirmed the degree of burn of the esophagus, and had evaluated the effect of melanin on healing processes, namely, faster recovery periods of damaged esophageal tissues. We have shown an increase in the expression of genes involved in the development of inflammation Ptgs2 and Tgfb1 in blood and esophageal tissues under alkali esophageal burn of 2 degree (AEB 2) conditions. After administration of melanin, the levels of expression of Ptgs2 and Tgfb1 genes in blood and esophageal tissues decreased compared to those in AEB 2 group. It was found that with AEB 2 in blood and esophageal tissues the content of pro-inflammatory (IL-1β, TNF-α) cytokines increased. After administration of melanin, there was a decrease in the content of pro-inflammatory cytokines compared with those of AEB 2 group. According to the obtained results the anti-inflammatory properties of this compound were demonstrated showing the prospect of melanin use as a substance contributing to chemical esophageal burn healing.
Keywords: alkaline burn of the esophagus, Ptgs2, Tgfb1 genes expression, cytokines, melanin
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