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The level of expression NOS2 and NFKB1 Genes in esophageal alkaline burns and when melanin is administered

Chornenka N.M., Raetska Ya.B., Huet A.S., Beregova T.V., Savchuk O.M., Ostapchenko L.I.


SUMMARY. In this study, we have shown an increase in the expression of pro-inflammatory agents Nos2 and Nfkb1 genes in the blood and mucous membrane of the esophagus under conditions of the 2nd degree esophageal alkaline burn (EAB 2). It was found that under AEB 2, the activity of eNOS and iNOS increased both in the blood and mucous membrane of the esophagus. After the introduction of melanin, there was a decrease in the expression of Nos2 and Nfkb1 genes in the blood and esophageal tissues as compared with AEB 2. Also, there was a decrease in the activity of eNOS and iNOS as compared with AEB 2, indicating the anti-inflammatory properties of this compound and the possibility of using melanin as a substance that promotes faster healing of chemical burns of the esophagus and prevents post-burn complications.

Key words: alkaline burn of the esophagus, gene expression Nos2, Nfkb1, nitric oxide, melanin

Tsitologiya i Genetika 2021, vol. 55, no. 4, pp. 26-33

  • Educational and Scientific Center Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, Ukraine

E-mail: nata.chornenka24

Chornenka N.M., Raetska Ya.B., Huet A.S., Beregova T.V., Savchuk O.M., Ostapchenko L.I. The level of expression NOS2 and NFKB1 Genes in esophageal alkaline burns and when melanin is administered, Tsitol Genet., 2021, vol. 55, no. 4, pp. 26-33.

In "Cytology and Genetics":
N. M. Chornenka, Ya. B. Raetska, A. S. Huet, T. V. Beregova, O. M. Savchuk & L. I. Ostapchenko Expression Level of the Nos2 and Nfkb1 Genes in the Conditions of Esophageal Alkaline Burns and with the Administration of Melanin, Cytol Genet., 2021, vol. 55, no. 4, pp. 317323
DOI: 10.3103/S0095452721040022


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