Цитологія і генетика 2022, том 56, № 5, 32-40
Cytology and Genetics 2022, том 56, № 5, 423–430, doi: https://www.doi.org/10.3103/S0095452722050024

Порівняльна характеристика цитогенетичних аномалій при різних формах мієлодиспластичних синдромів

Андреєва С.В., Корець К.В., Скороход І.М., Стародуб Г.С.

  1. ДУ «Інститут гематології та трансфузіології НАМН України», Київ
  2. ДУ «Науково-практичний медичний центр дитячої кардіології та кардіохірургії МОЗ України», Київ
  3. Медична лабораторія ТОВ «ІММД», Київ

Проведено співставлення цитогенетичних та молекулярно-цитогенетичних перебудов клітин кісткового мозку у 251 пацієнтів на час встановлення діагнозу мієлодиспластичних синдромів (МДС) та у 7 пацієнтів – при трансформації у вторинну гостру мієлоїдну лейкемію. Встановлена значна гетерогенність каріотипів за структурою клонів у всіх виділених формах МДС та у трансформованих з МДС вторинних гострих мієлоїдних лейкеміях, що свідчить про різноманітний генетичний склад клітин кісткового мозку. Показано, що еволюція клональних аномалій хромосом є універсальним механізмом формування аномальних клонів. Відмічено зростання частоти псевдодиплоїдних та гіподиплоїдних клонів в залежності від складності форми МДС (псевдодиплоїдний від 4,5% при МДС з однолінійною дисплазією (РА) до 27,3 % при МДС з надлишком бластів (РАНБ 1-2); гіподиплоїдний – від 4,5 % при РА до 18,2 % при РАНБ 1-2), що пов’язана з втратою генетичного матеріалу. В групі РА частіше реєстрували втрати генетичного матеріалу, у вигляді делецій (57,9 %). До структурних перебудов частіше залучалася хромосома 11 (31,6 %).

Ключові слова: мієлодиспластичні синдроми, кістковий мозок, аномалії хромосом

Цитологія і генетика
2022, том 56, № 5, 32-40

Current Issue
Cytology and Genetics
2022, том 56, № 5, 423–430,
doi: 10.3103/S0095452722050024

Повний текст та додаткові матеріали

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