Dalivelya O.V., Savina N.V., Kuzhir T.D., Goncharova R.I.

DNA-repair modulation using derivatives of 1,4-dihydroisonicotinic aсid as an example

TSitologiia i genetika 2005, v 39, Issue 5, 62-72

The influence of two derivatives of 1,4-dihydroisonicotinic acid on DNA-repair involved in chemical mutagenesis in Drosophila germ cells has been investigated. The compounds tested decreased the level of EMS-induced chromosome breakage and point mutations due to stimulation of maternal repair of DNA primary damage induced in spermatozoa as well as due to activation of DNA-repair in larvae and imago premeiotic stages of Drosophila males. Deficiency of DNA-repair systems leads to decrease in female and male germ-cell sensitivity to antimutagen action..

Dalivelya O.V., Savina N.V., Kuzhir T.D., Goncharova R.I. DNA-repair modulation using derivatives of 1,4-dihydroisonicotinic aсid as an example // Tsitol Genet. – 2005. – 39(5). – P. 62-72.