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Dalivelya O.V., Savina N.V., Kuzhir T.D., Goncharova R.I.
DNA-repair modulation using derivatives of 1,4-dihydroisonicotinic añid as an example
Cytology and Genetics 2005, v 39, number 5, 62-72
The influence of two derivatives of 1,4-dihydroisonicotinic acid on DNA-repair involved in chemical mutagenesis in Drosophila germ cells has been investigated. The compounds tested decreased the level of EMS-induced chromosome breakage and point mutations due to stimulation of maternal repair of DNA primary damage induced in spermatozoa as well as due to activation of DNA-repair in larvae and imago premeiotic stages of Drosophila males. Deficiency of DNA-repair systems leads to decrease in female and male germ-cell sensitivity to antimutagen action..
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