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The effect of carcinoma 3LL on mouse fetuses in syngeneic and allogeneic pregnancies
Effects of experimental Lewis lung carcinoma on embryogenesis was studied. It is shown, that maternal Lewis carcinoma possessed the pronounced embryolethal and teratogenic effects. The injuries of formation of fetoplacental units due to the fetal growth retardation, increase in frequency of congenital malformations were observed. Embryopathies were characterized by polymorphism of significance (degree of heaviness) and the range of defects. The frequency and pronouncement of fetal defects of development under syngenic pregnancy in comparison with allogenic pregnancy increased. We suggest to consider the interaction of pregnancy and cancer as endogenous teratogenic process, which changes the "microclimate" in which the realization of embryonal genetic programme takes place.
Tsitologiya i Genetika 1998, vol. 32, no. 1, pp. 120-126
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