TSitologiya i Genetika 2010, vol. 44, no. 1, 25-29
Cytology and Genetics , vol. , no. , , doi: https://www.doi.org/

Formation of multicellular aggregates under different conditions of microenvironment

Garmanchouk L., Perepelytsina O., Sydorenko M., Ostapchenko L.I.

  • Department of biotechnical problems of diagnostics Institute problems of cryobiology and criomedicine NAN Ukraine, Kyiv
  • Taras Shevchenko Kyiv National University

Multicellular aggregates (spheroids) represent an intermittent level between monolayer growing cells and tissue culture. Spheroids are rather objective model of the three-dimensional growth and organization, the cell-to-cell interactions and influence of microenvironmental conditions on tumour microaggregates. In our work formation and growth of spheroids depends on concentration of CMC and FCS. Conditions of microenvironment influence on intensiveness of proliferation as well as on cells adhesiveness and formation of microaggregates.

Keywords: Багатоклітинні агрегати, сфероїди, карбокси-метил-целюлоза, MCF-7, проліферація, адгезія

TSitologiya i Genetika
2010, vol. 44, no. 1, 25-29

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