Study of genetic determination of metabolic syndrome base clinical components

Shtandel S.A., Barilyak I.R., Kravchun N.A., Snegurskaya I.A., Miloslavskiy D.K., Levchenko T.P.

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Genetic analysis was carried out on the material including clinic and genealogical data about 510 patients with type 2 Diabetes Mellitus, 445 Essential Hypertension individuals, 239 abdominal obesity persons and their 1^st degree relatives. It has been shown that the Essential Hypertension and abdominal obesity distribution in the population and families can be described by means of a variants polygene model with essential influence of the major genes. Gene complexes of predisposition to obesity, Essential Hypertension and Type 2 Diabetes Mellitus are independent, however, their liabilities are covered.

Tsitologiya i Genetika 2010, vol. 44, no. 1, pp. 57-64

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Shtandel S.A., Barilyak I.R., Kravchun N.A., Snegurskaya I.A., Miloslavskiy D.K., Levchenko T.P. Study of genetic determination of metabolic syndrome base clinical components, Tsitol Genet., 2010, vol. 44, no. 1, pp. 57-64.