Gene therapy based on human mesenchymal stem cells : Strategies and methods

Shakhbazau A.V., Kosmacheva S.M., Kartel N.A., Potapnev M.P.

Review 

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Major technologies of transient and stable transgene expression in hMSC are reviewed. Properties and efficiencies of recombinant lentiviruses, adenoviruses, AAV and baculoviruses used for hMSC transduction are compared. The aims of transgenesis include directed differentiation of hMSC, function improvement, correction of pathology factors and proliferatrion control, as well as many basic research challenges.

Key words: mesenchymal stem cells (hMSC), transduction, gene therapy

Tsitologiya i Genetika 2010, vol. 44, no. 1, pp. 76-82

E-mail: shakhbazau gmail.com

Shakhbazau A.V., Kosmacheva S.M., Kartel N.A., Potapnev M.P. Gene therapy based on human mesenchymal stem cells : Strategies and methods, Tsitol Genet., 2010, vol. 44, no. 1, pp. 76-82.