TSitologiya i Genetika 2011, vol. 45, no. 2, 10-15
Cytology and Genetics 2011, vol. 45, no. 2, 70-74, doi: https://www.doi.org/10.3103/S0095452711020101

Investigations of genotoxic activity of antimicrobial/antiviral agent FS-1 in human lymphocytes and tumor cell

Nersesyan A., Ilin A., Kulmanov M.

  • National Center of Oncology, Yerevan, Armenia
  • Institute of Cancer Research, Medical University of Vienna, Austria
  • Scientific Center for Anti-Infectious Drugs, Almaty, Kazakhstan
A very promising antiviral and antimicrobial agent FS-1 was studied for its ability to induce DNA damage and micronuclei in human tumor cell lines HeLa and Caco-2 at concentrations of 200, 500 and 1000 mg/ml without exogenous metabolic activation. The compound was additionally tested for DNA damaging ability in human lymphocytes at concentrations of 200, 400 and 800 mg/ml. Neither DNA damage nor micronucleus formation was observed after treatment of all types of cells with FS-1. Based on these results, FS-1 can be further studied for its safety to humans for potential application in clinical medicine as an antimicrobial/antiviral drug.

Keywords: DNA damage; tumor cell lines HeLa and Caco-2; human lymphocytes; comet assay

TSitologiya i Genetika
2011, vol. 45, no. 2, 10-15

Current Issue
Cytology and Genetics
2011, vol. 45, no. 2, 70-74,
doi: 10.3103/S0095452711020101

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