Q192R polymorphism of PON-1 gene in type 2 diabetic patients

Polymorphism of PON-1 gene in 192 position of amino acid sequence of enzyme paraoxonase 1 was studied. For this research we have used the blood samples of 96 patients with T2DM and 123 healthy habitants of Kharkiv. Frequencies of alleles for the patients (р_Q = 0,65, р_R = 0,35) and the healthies (р_Q = 0,70 and р_R = 0,30) did not differentiate meaningfully. Distribution of the genotypes for healthy people does not correspond to Hardy-Weinberg equilibrium, the patients of T2DM have surplus of both homozygotes and shortage of heterozygotes. The risk of illness of T2DM for QQ homozygotes is 1,46-times higher and for QR heterozygotes is two times lower than on the average in the population (2 %). The risk of illness of T2DM for RR homozygotes 1,86-times exceeds a middle population risk but is not significant.

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