Antiviral activity of extracts of transgenic cichory and lettuce plants with the human interferon alpha­2b gene

Matvieieva N.А., Kudryavets Yu.I., Lichova O.O., Schachovsky A.M., Bezdenezhnykh N.O., Kvasko O.Yu.

SUMMARY. Biological activity of protein extracts from transgenic plants of chicory Cichorium intybus L. and lettuce Lactuca sativa L. with human interferon α2b gene was investigated against vesicular stomatitis virus. It was shown that the extracts from the hairy roots of chicory and lettuce transformed by A. rhizogenes possess the antiviral activity 1620…5400 IU/g weight, and the extracts from leaves of the plants transformed by
A. tumefaciens – till 9375 IU/g weight. Dependence of plant extract biological activity on the transformation vector was shown.

Key words: Cichorium intybus L., Agrobacterium rhizogenes, Agrobacterium tumefaciens, interferon α2b, genetic transformation, аntiviral activity

Tsitologiya i Genetika 2012, vol. 46, no. 5, pp. 28-35

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Matvieieva N.А., Kudryavets Yu.I., Lichova O.O., Schachovsky A.M., Bezdenezhnykh N.O., Kvasko O.Yu. Antiviral activity of extracts of transgenic cichory and lettuce plants with the human interferon alpha­2b gene, Tsitol Genet., 2012, vol. 46, no. 5, pp. 28-35.

In "Cytology and Genetics":
N. A. Matvieieva, Yu. I. Kudryavets, A. A. Likhova, A. M. Shakhovskij, N. A. Bezdenezhnykh, E. Yu. Kvasko Antiviral activity of extracts of transgenic chicory and lettuce plants with the human interferon α2b gene, Cytol Genet., 2012, vol. 46, no. 5, pp. 285-290
DOI: 10.3103/S0095452712050076