TSitologiya i Genetika 2012, vol. 46, no. 4, 66-72
Cytology and Genetics 2012, vol. 46, no. 4, 246-250, doi: https://www.doi.org/10.3103/S0095452712040044

Cyclooxigenase-1 gene polymorphism and aspirin resistance

Bondar T.N., Kravchenko N.A.

SUMMARY. The literature data concerning structure of cyclooxigenase-1 – the key enzyme in prostaglandin biosynthesis and the main target of anti-platelet therapy with the use of acetylsalicilic acid are presented in the review. The data on cyclooxigenase-1 gene polymorphism, distribution of the revealed variants in various populations and their possible correlation with biochemical and functional aspirin resistance are presented.

Keywords: cyclooxigenase-1, thromboxane, polymorphism of cyclooxigenase-1 gene, platelets aggregation, aspirin, aspirin resistance

TSitologiya i Genetika
2012, vol. 46, no. 4, 66-72

Current Issue
Cytology and Genetics
2012, vol. 46, no. 4, 246-250,
doi: 10.3103/S0095452712040044

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