Bioinformatics comparison of human and plant phosphatomes

SUMMARY. The study presents the results of bioinformatic comparison of protein phosphatases from higher plants and human phosphatom (150 sequences). Based on sequence and profile comparison with known catalytic domains, 204 plant homologues from Physcomitrella patens and Arabidopsis thaliana where selected. Clustering of joint group of plant and mammalian protein phosphatases revealed fundamental differences in plant and human phosphatomes. At the same time, it was shown significant differences in the set of protein phosphatases in P. patens, A. thaliana, and such monocots as Orysa sativa and Zea mays.

Keywords: protein phosphatases, human phosphatome, plant phosphatome, bioinformatics, phylogeny