SUMMARY. The molecular-genetic testing of the polymorphic rs 2981579 (C > T) locus of the FGFR2 gene as the marker of increased predisposition to the development of mesial occlusion was conducted in 110 patients with mesial occlusion and in 103 general-population control subjects of Ukraine. Overall, we found rs2981579 polymorphism in the FGFR2 gene associated with mesial occlusion (OR = 1,67, 95 % CI = 1,14–2,45, р = 0,009). Compared to CC carriers, TT+CT carriers had a 3,21-fold increased odds of mesial occlusion (95 % CI = 1,57–6,57, P = 0.001). We found protective effect of the homozygous alelle C on mesial occlusion development (OR = 0,31, p = 0,001).This is the first published data on polymorphisms FGFR2 rs 2981579 (C>T) in patients with mesial occlusion.
Keywords: mesial occlusion, gene polymorphism, FGFR2
