Molecular and genetic aspects of the Helicobacter pylori interaction with cells of the gastric mucosa

Sukhan D.S., Vernigorodskiy S.V., Haidukov N.V., Ludkevich H.P.

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SUMMARY. The modern views on the classical determinants of Helicobacter pylori virulence, the pathogenetic effects of phosphorylation and the process of translocation of CagA into the cells of the gastric mucosa (GM) were analyzed, and the surface membrane receptors of VacA binding to the epithelial cells of the GM were characterized in this study. The necessity of carrying out genetic typing of Helicobacter pylori to determine the potential virulence of a microorganism in order to predict the course of H. pylori-associated diseases and to select targeted therapy has been substantiated.

Key words: Helicobacter pylori, CagA, VacA, gastric pathology

Tsitologiya i Genetika 2019, vol. 53, no. 6, pp. 71-78

E-mail: d.suxan gmail.com, vernset ukr.net, nikita.omarov gmail.com, ludkeveech gmail.com

Sukhan D.S., Vernigorodskiy S.V., Haidukov N.V., Ludkevich H.P. Molecular and genetic aspects of the Helicobacter pylori interaction with cells of the gastric mucosa, Tsitol Genet., 2019, vol. 53, no. 6, pp. 71-78.

In "Cytology and Genetics":
D. S. Sukhan, S. V. Vernygorodskyi, N. V. Haidukov & H. P. Ludkevich Molecular and Genetic Aspects of Helicobacter pylori Interaction with Cells of Gastric Mucosa, Cytol Genet., 2020, vol. 54, no. 2, pp. 147–153
DOI: 10.3103/S0095452720020139

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