TSitologiya i Genetika 2020, vol. 54, no. 6, 70-72
Cytology and Genetics 2020, vol. 54, no. 6, 574–581, doi: https://www.doi.org/10.3103/S0095452720060080

Association of MYNN, TERT and TERC gene polymorphisms with prostate cancer in Turkish population

F. Polat, S. B. Dİler, G. Bİngöl

  1. Department of Mathematics and Science Education, Faculty of Education, Kocaeli University, Kocaeli, Turkey
  2. Department of Biotechnology, Faculty of Science and Letters, Nigde Ömer Halisdemir University, Niğde, Turkey
  3. Biomedical Engineering, Faculty of Engineering and Natural Sciences, Ankara Yıldırım Beyazıt University, Ankara, Turkey

This study aims to determine whether there is any relationship between prostate cancer development and MYNN rs10936599, TERC rs2293607 and hTERT MNS16A polymorphisms in Turkish population. The research was comprised of 77 individuals with prostate cancer and 116 healthy individuals without history of cancer. Genotyping analysis was performed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The results obtained were evaluated using the chi-square test and unconditional logistic regression analysis. In the study, the GG genotype of TERC rs2293607 polymorphism, the VNTR-243/243 genotype of TERT MNS16A polymorphism, and allele 243 were found to be statistically significant between the patient and control groups (ORc = 3.250, 95%CI = 1.176–8.980, pc = 0.023; ORc = 3.09, 95%CI = 1.238–7.717, pc = 0.016; OR = 0.638, 95%CI = 0.416-0.978, p = 0.038). On the other hand, there was no significant relationship between MYNN rs109365999 polymorphism and prostate cancer in Turkish population. In conclusion, the obtained data show that the TERC rs2293607 and TERT MNS16A VNTR-243/243 polymorphisms might be potential risk factors for the development of prostate cancer in Turkish population and might be suggested as prognostic markers.

Keywords: MYNN, TERT, TERC, prostate cancer, Turkish population

TSitologiya i Genetika
2020, vol. 54, no. 6, 70-72

Current Issue
Cytology and Genetics
2020, vol. 54, no. 6, 574–581,
doi: 10.3103/S0095452720060080

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