eNOS and VEGF variants might increase the risk of pancreatic cancer

Dagmura H., Yigit S., Gumusay O., Nursal A.F., Daldal E., Karakus N.

MD, Department of General surgery and surgical oncology, Gaziosmanpasa University, School of Medicine, Kaleardi Mah. Tokat (60250), Turkey
Associate Professor, Gaziosmanpasa University, Kaleardi Mah. Tokat (60250), Turkey
Associate professor of Medical Oncology, Gaziosmanpasa University, Kaleardi Mah. Tokat (60250), Turkey
Associate Professor of Genetics, Hitit University, Department of Genetics, Corum, Turkey
Assistant professor of General Surgery, Gaziosmanpasa University, Kaleardi Mah. Tokat (60250), Turkey
Associate Professor of Medical Biology, Gaziosmanpasa University, Kaleardi Mah. Tokat (60250), Turkey

Endothelial nitric oxide synthase (eNOS) is essential in chronic inflammation and carcinogenesis. The association between variants in vascular endothelial growth factor (VEGF) and several cancers still remains uncertain. We studied whether there is a relation between eNOS/VEGF variants and risk of pancreatic cancer (PC). This prospective casecontrol study included 76 PC patients (28 women and 48 men) and 100 healthy controls. Blood samples from all participants were genotyped for eNOS variable number tandem repeat (VNTR) and VEGF insertion/deletion (I/D) variants by PCR. There was a significant difference between groups for the eNOS intron 4 VNTR genotype distributions (p = 0.01). eNOS 4a/4b and 4b/4b genotypes were higher in patients with PC group compared to controls while eNOS 4a/4b genotype was more prevalent in control group than in patient group. Significant differences were observed between groups for the VEGF I/D variant genotype and allele frequencies (p ˂ 0.00, and p ˂ 0.00). VEGF I/D variant I/I genotype and I allele increased in patient group than controls. A statistically significant association was observed when the patients were compared with the controls according to D/D+D/I versus D/D (p ˂ 0.00, OR: 0.094, 95 % CI: 0.03–0.22) We provided evidence that eNOS VNTR and VEGF I/D variants might influence the development of PC.

Keywords: pancreatic cancer, eNOS, VEGF, variant

TSitologiya i Genetika
2021, vol. 55, no. 2, 72-74

Cytology and Genetics
2021, vol. 55, no. 2, 177–182,
doi: 10.3103/S0095452721020031

Full text and supplemented materials

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