SUMMARY. Nowadays the possible influence of the coronavirus infection onto cartilage degeneration and synovial mem-brane inflammation during joint chronic pathology – osteoarthritis – remains largely unelucidated. The aim of the presented work is to analyze the ТGFB1, FOXO1 and COMP gene expression and free radical generation intensity in blood of patients suffering from osteoarthri-tis after beating the SARS-CoV2 infection. The work was carried out using molecular genetics and bio-chemistry methods. The decrease of the ТGFB1 and FOXO1 expression level was shown to be more evident in the osteoarthritis patients having beaten COVID-19 if compared to the group with knee joint osteoarthritis, during simultaneous and more prominent diminishing of both superoxide dismutase and catalase activity (possibly indicating cell redox state disruption and TGF-β1-FoxO1 signaling attenuation) in patients with osteo-arthritis having beaten SARS-CoV2 disease. At the sa-me time the more prominent decrease of COMP gene expression level was demonstrated in patients with osteoarthritis having beaten COVID-19 comparing to the patient group with knee joint osteoarthritis in the event of more intense increase of the COMP concentration in patients with osteoarthritis after the SARS-CoV2 in-fection. This data indicates more significant activation of cell destructive processes after beating the infection as well as further pathology progression.
Keywords: SARS-CoV-2, ТGFB1, FOXO1, COMP gene expression, osteoarthritis, COMP, catalase, superoxide dismutase
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