Polymorphism 896A/G of TLR4 gene rather than 1196C/T and 2258G/A of TLR2 gene determines severe and complicated course of atopic dermatitis in children

Levchenko L.Y., Izmailova О.V., Shlykova O.A., Kaidashev I.P.

SUMMARY. The prevalence of TLR2 gene polymorphisms 2258G/A, 896A/G and 1196C/T of TLR4 gene in children with atopic dermatitis (AD) as compared to the control group has been examined. Results of the distribution analysis of genotypes and alleles of TLR2 and TLR4 genes explicitly show that TLR4 gene mutant allele 896G is detected more frequently in children with AD with increased susceptibility to acute viral respiratory infections (9,3 %) as compared to the control group (χ² = 4,33; p = 0,038). Analysis of association of clinical manifestations of the disease showed a greater frequency of a light flow of blood pressure (p = 0,0001) – the children of AD patients with normal resistance of the organism; a greater frequency of the disease an average severity (p = 0,0033), concomitant allergic rhinitis (AR) and/or bronchial asthma (BA) (p = 0,0355), concomitant AR (p = 0,0673) – in patients with AD with increased susceptibility to acute viral respiratory infections. In AD patients with a mutant allele of the gene TLR4 896G frequently identified: a severe course of disease (p = 0,0485) associated adenoid vegetation in conjunction with AR and/or BA (p = 0,0248), concomitant adenoid vegetation in conjunction with the AR (p = 0,0053) compared with patients with «wild» allele.

Key words: polymorphism, Тoll-like receptors, atopic dermatitis

Tsitologiya i Genetika 2013, vol. 47, no. 3, pp. 46-53

E-mail: kaidashev yandex.ru

Levchenko L.Y., Izmailova О.V., Shlykova O.A., Kaidashev I.P. Polymorphism 896A/G of TLR4 gene rather than 1196C/T and 2258G/A of TLR2 gene determines severe and complicated course of atopic dermatitis in children, Tsitol Genet., 2013, vol. 47, no. 3, pp. 46-53.

In "Cytology and Genetics":
L. Yu. Levchenko, O. V. Izmailova, O. A. Shlykova, I. P. Kaidashev TLR4 896A/G gene polymorphism, rather than the TLR4 1196C/T and TLR2 2258G/A gene polymorphisms, determines the severe and aggravated course of atopic dermatitis in children, Cytol Genet., 2013, vol. 47, no. 3, pp. 167-173
DOI: 10.3103/S0095452713030067