Genotoxic effects of radiation and hyperthermia in linear mice with different radiation sensitivity

SUMMARY. Peculiarities of repair of DNA injuries induced by radiation and hyperthermia and their realization on chromosomal level in bone marrow cells of experimental animals with different radiation sensitivity were studied. It is shown that radiomodification efficiency of mild hyperthermia is higher for radioresistant animals. More intensive elimination of chromosomal injuries the level of which in remote terms of examination corresponds to the control value, is observed. In the group of animals with higher radiation sensitivity prolonged thermal potentiation of radiation effects on chromosomal level is determined.

Keywords: DNA repair, chromosome aberrations, radiation sensitivity, hyperthermia