Показано зниження рівня експресії гена Tjp1 при загоюванні повношарових вирізаних площинних ран шкіри щурів на тлі активування вільнорадикальних процесів (зростання вмісту супероксидного аніон-радикалу). Відновлення рівня експресії цього гена може бути опосередковано зростанням рівня експресії гена Tlr2. При застосуванні меланіну за тих самих умов рівень експресії Tjp1, як і вміст супероксидного аніон-радикалу, швидше наближався до контрольних значень за відсутності гіперекспресії гена Tlr2, під час відновлення цілісності шкіри.
РЕЗЮМЕ. Показано снижение уровня экспрессии гена Tjp1 при заживлении полнослойных вырезанных плоскостных ран кожи крыс на фоне активации свободнорадикальных процессов (увеличение содержания супероксидного анион-радикала). Восстановление уровня экспрессии этого гена может быть опосредовано ростом уровня экспрессии гена Tlr2. При применении меланина при тех же условиях уровень экспрессии Tjp1, как и содержание супероксидного анион-радикала, быстрее приближалось к контрольным значениям при отсутствии гиперэкспрессии гена Tlr2, во время восстановления целостности кожи.
Ключові слова: експресія генів Tjp1, Tlr2, повношарові вирізані площинні рани шкіри, меланін
экспрессия генов Tjp1, Tlr2, полнослойные вырезанные плоскостные раны кожи, меланин
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